Expression of bcl-2,bcl-6,CD10 Protein and Their Significance in Subgroups of Diffuse Large B-cell Lymphoma

Objective To investigate the expression of bcl-2,bcl-6,CD10 protein and their significance in subgroups of diffuse large B-cell lymphoma. Methods Immunohistochemistry technique(SP method) was used to assess the expression levels of bcl-2,bcl-6,CD10 protein in 60 cases of diffuse large B-cell lymphoma. Results Expression of bcl-2,bcl-6 and CD10 protein was found in 33/60(55.0%),29/60(48.3%),28/60(46.7%) cases,respectively.The CD10/bcl-6 patterns were as follows: CD10(+)/bcl-6(+) 15 cases,25%;CD10(+)/bcl-6(-)13 cases, 21. 7 %; CD10 ( - ) / bcl-6 ( + ) 14 cases, 23. 3 %;CD10( - ) / bcl-6 ( - ) 18 cases, 30 %。Expression levels of the bcl-2 protein in CD10 ( + ) / bcl-6 ( + ) pattern was higher than that in CD10 ( - ) / bcl-6 ( - ) pattern ( P = 0. 037) . Conclusion 　The bcl-2 protein may be of value to distinct subgroup s of diffuse large B-cell lymphoma.