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LIU Zhi-zhong, LIN Ju-sheng, CAI Xiao-kun, LI Xiao-sheng, HUANG Wen-ying. Effects of Hypoxia-inducible Factor-1alpha on Human Hepatic Cancer Cell Line Hep G2 in Vivo[J]. Cancer Research on Prevention and Treatment, 2005, 32(06): 344-345. DOI: 10.3971/j.issn.1000-8578.644
Citation: LIU Zhi-zhong, LIN Ju-sheng, CAI Xiao-kun, LI Xiao-sheng, HUANG Wen-ying. Effects of Hypoxia-inducible Factor-1alpha on Human Hepatic Cancer Cell Line Hep G2 in Vivo[J]. Cancer Research on Prevention and Treatment, 2005, 32(06): 344-345. DOI: 10.3971/j.issn.1000-8578.644
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Effects of Hypoxia-inducible Factor-1alpha on Human Hepatic Cancer Cell Line Hep G2 in Vivo

  • 1. Hepatic Diseases Department of Tongji Hospital, Tongji Medical College, Wuhan 430022, China;2. Department of Neural Surgery, Xiehe Hospital Affiliated Tongji Medical College, Huazhong University of Science and Technology ;3. The First People's Hospital of Chenzhou Cit y ( * Corres ponding Author)

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  • Received Date: May 12, 2004
  • Revised Date: October 25, 2004
    Abstract
  • Objective 　To study the effect of hypoxia-inducible factor-1alpha ( HIF-1α) on hepatic cancer cell line Hep G2 growth in vivo and its mechanisms. Methods 　Hep cells (1 (106 / mouse) were inoculated subcutaneously into 20 nude mice. The weights of subcutaneous tumor were detected. The resected specimens were made into paraffin-embedded sections. The expressions of HIF-1α and vascular endothelial growth factor (VEGF) proteins were analyzed by Western blot and Immohistochemistry ( ISH) . Results 　The growth rates of HIF-1α treating hepatic cancer cells Hep G2 were significantly increased. Conclusion 　 The HIF-1α could promote hepatic cancer cell line Hep G2 growth in vivo and it s mechanism may be due to the fact that it can promote vascular growth.
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    • 1. Hepatic Diseases Department of Tongji Hospital, Tongji Medical College, Wuhan 430022, China;2. Department of Neural Surgery, Xiehe Hospital Affiliated Tongji Medical College, Huazhong University of Science and Technology ;3. The First People's Hospital of Chenzhou Cit y ( * Corres ponding Author)

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