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KONG Yan, JIANG Da, ZHANG Min. Effect of Thal idomide on VEGF-C and Its Receptor Expression in Human Breast Cancer Cell Lines[J]. Cancer Research on Prevention and Treatment, 2007, 34(12): 921-923. DOI: 10.3971/j.issn.1000-8578.61
Citation: KONG Yan, JIANG Da, ZHANG Min. Effect of Thal idomide on VEGF-C and Its Receptor Expression in Human Breast Cancer Cell Lines[J]. Cancer Research on Prevention and Treatment, 2007, 34(12): 921-923. DOI: 10.3971/j.issn.1000-8578.61
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Effect of Thal idomide on VEGF-C and Its Receptor Expression in Human Breast Cancer Cell Lines

  • 1. Oncology Department of the Fourth Hospital of Heibei Medical University, Shijiazhang 050011, China;2. Oncology Department of the People Hospital of Xingtai

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  • Corresponding author:

    JIANG Da

  • Received Date: January 04, 2007
  • Revised Date: May 31, 2007
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  • Objective 　To assess the effect s of thalidomide on VEGF-C and KDR expression in human breast cancer cell lines, MCF-7 and MDA-MB-231. Methods 　Breast cancer cells were treated with thalidomide, then cell proliferation were examined by the method of MTT. The level of VEGF-C mRNA expression was distinguished by semi-quantitative RT-PCR technique. Flow cytometry was applied to examine the protein expression of VEGF-C and KDR. Results 　Within the concent ration of (60～120) μg/ml, thalidomide strongly inhibited proliferation of MCF27 and MDA-MB-231. When the drug is 60 μg/ml, thalidomide can inhibit the mRNA expression of VEGF-C and the protein expression of VEGF-C and KDR. Conclusion 　Within a certain drug concent ration, thalidomide can inhibit human breast cancer cell proliferation. Its role of inhibiting angiogenesis maybe relate with down regulating the expression of VEGF-C and KDR.
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