A Study of Antisense Oligodeoxynucleotides As A Chemo-Sensitizer to Cytotoxic Agents on Proliferation of Breast Cancer Cell Lines in Vitro

Objective To study the inhibitory effects of HER2 specific antisense oligodeoxynucleotide HA6722 administered along or in combination with paclitaxel on proliferation of breast cancer cell lines. Methods MDA-MB-453 and MDA-MB-231 cell lines, which are HER2 over- and normal-espression, respectively, were set as experimental cells. Inhibitory effects of HA6722 alone or in combination with paclitaxel on these cells were detected by means of methyl thiazolyl blue (MTT); apoptosis was detected by means of TdT-Me...