Analysis of Promoter Hypermethylation of p16 Gene and DAPK Gene in Sera from Primary Liver Cancer Patien

Objective To analyze the aberrant methylation of p16 gene and DAPK gene in sera from primary liver cancer patients and to evaluate the clinical significance. Methods A methylation-specific PCR was performed for the detection of promoter hypermethylation of p16 gene and DAPK gene in blood DNA from 64 cases of PLC patients. The relation of the aberrant methylation of p16 gene and DAPK gene and the clinical pathological data was analyzed. Results 76.6%(49/64)of the sera from 64 cases of PLC patients showed hyp...