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YUAN Peng, HUANG Yan-hong, XIN Xiao-yan, SONG Hui, TIAN Shuang, YU Yue-cheng, WANG De-tang. Effects of Genistein on Proliferation, Apoptosis and Cisplatin Sensitivity of Drug-resistant Human Ovarian Carcinoma Cell SKOV-3[J]. Cancer Research on Prevention and Treatment, 2006, 33(03): 187-190. DOI: 10.3971/j.issn.1000-8578.433
Citation: YUAN Peng, HUANG Yan-hong, XIN Xiao-yan, SONG Hui, TIAN Shuang, YU Yue-cheng, WANG De-tang. Effects of Genistein on Proliferation, Apoptosis and Cisplatin Sensitivity of Drug-resistant Human Ovarian Carcinoma Cell SKOV-3[J]. Cancer Research on Prevention and Treatment, 2006, 33(03): 187-190. DOI: 10.3971/j.issn.1000-8578.433
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Effects of Genistein on Proliferation, Apoptosis and Cisplatin Sensitivity of Drug-resistant Human Ovarian Carcinoma Cell SKOV-3

  • Department of Obstetrics and Gynecology; Xijing Hospital; The Fourth Military Medical University; Xi'an 710032; China

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  • Corresponding author:

    XIN Xiao-yan

  • Received Date: July 24, 2005
  • Revised Date: October 20, 2005
    Abstract
  • Objective To study the effects of genistein on proliferation, apoptosis and cisplatin sensitivity of drug-resistant ovarian carcinoma cell skov-3. Methods MTT assay was used to analyze growth inhibitory effect of genistein alone and with cisplatin on SKOV-3 cell. Cell cycle arrest and apoptosis was meas-ured by flow cytometry (FCM). Results Genistein exerted inhibitory effect on SKOV-3 cell in a concen-tration-dependent way and significantly enhanced its sensitivity to cisplatin(P< 0.05). Generally, cisp...
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    WANG De-tang

    • Department of Obstetrics and Gynecology; Xijing Hospital; The Fourth Military Medical University; Xi'an 710032; China

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