Study of the Telomera se Activity in Human Lung Cancer

Objective To investigate the possibility of using telomerase as a tumor marker for human primary lung cancer. Methods 81 human lung specimens, comprising 50 carcinoma tissues, 24 chronicmucit is tissues and 7m etaplasia or atypia tissues,were examined for telomerase activity by TRAP assay. Results 41 of 50 the carcinoma tissue specimens were positive for telomerase activity with a positive rate of 82%, 4 of 7 atypical tissue specimens and two of 24 chronic mucitis tissue specimens were positive. Conclusion Telom erase is a tumor specific gene marker.