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GUO Renhong, TANG Guidi, PAN Liangxi, HUANG Xinen, FENGJifeng, ZHANG Quanan. Cl inical Observation of Docetaxel Combined with Low2dose Cisplatin for Treating Advanced Non2small Cell Lung Cancer in Elderly Patients[J]. Cancer Research on Prevention and Treatment, 2008, 35(01): 52-54. DOI: 10.3971/j.issn.1000-8578.3223
Citation: GUO Renhong, TANG Guidi, PAN Liangxi, HUANG Xinen, FENGJifeng, ZHANG Quanan. Cl inical Observation of Docetaxel Combined with Low2dose Cisplatin for Treating Advanced Non2small Cell Lung Cancer in Elderly Patients[J]. Cancer Research on Prevention and Treatment, 2008, 35(01): 52-54. DOI: 10.3971/j.issn.1000-8578.3223
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Cl inical Observation of Docetaxel Combined with Low2dose Cisplatin for Treating Advanced Non2small Cell Lung Cancer in Elderly Patients

  • 1. Department of Medical Oncolog y, J iangsu Tumor Hos pi tal, N anj ing 210009, China; 2. Depart2 ment of Medical Oncology, N anj ing Tumor Hos pi tal

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  • Received Date: January 08, 2007
  • Revised Date: March 04, 2007
    Abstract
  • Objective 　To evaluated the efficacy and toxicity of Docetaxel combined with low2dose Cisplatin as alternative chemotherapy for elderly patient s with advanced non small cell lung cancer (NSCLC) . Methods 　Thirty2one patient s were enrolled in the study. Each was t reated as following : Docetaxel 40mg/ m2 infusion once per week for two weeks ; Cisplatin 14mg/ m2 / d infusion on day1～5. Af ter 2 con2 secutive t reatment course, each for 4 weeks, evaluation of the short2term efficacy and adverse effect s was carried out . Results 　The overall response rate was 32. 3 %(10/ 31) . CR0 (0 %), PR10 (32. 3 %), SD16 (51. 6 %), PD5 (16. 1 %), median OS was 10. 3 months. Hematologic toxicities, which were mild, in2 cluded grade Ⅲ～ Ⅳ neut ropenia in 29. 0 %(9/ 31) . The major non2hematologic toxicity was weakness (45. 2 %) . Conclusion 　Weekly Docetaxel combined with low2dose Cisplatin as alternative chemotherapy is encouraging for elderly patient s with advanced NSCLC.
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    • 1. Department of Medical Oncolog y, J iangsu Tumor Hos pi tal, N anj ing 210009, China; 2. Depart2 ment of Medical Oncology, N anj ing Tumor Hos pi tal

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