Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase and Their Significance in Endometrial Carcinoma

Objective To investigate the expression of COX-2 and iNOS in endometrial carcinomas and to evaluate the correlation between the expression of COX-2,iNOS and clinicopathologic variables in these patients. Methods The expression of COX-2 protein and iNOS protein in thirty endometrial carcinomas surgical specimens were examined by immunohistochemical technique. COX-2 and iNOS mRNA expression was examined by reverse-transcription polymerase chain reaction (RT-PCR) in endometrial carcinomas,adjacent nontumourou...