A Study on Relationships of nm23、Bcl-2、PCNA Expression with the Invasion、Metastasis of Gastric Adenocarcinom

Objective To explore the possible mechanism of cancer invasion and metastasis. Methods The expressions of nm23、Bcl-2 and PCNA were investigated in 65 cases of primary gastric adenocarcinoma by using S-P immunohistochemical staining. Results (1) The expression of nm23 was correlated with tumor differentiation and metastasis;Bcl-2 was correlated with tumor invasion and metastasis;as well as PCNA expression was correlated with tumor differentiation,invasion and metastasis.(2) There was a striking association between PCNA expression and nm23 expression,wheras an inversing associaton between PCNA expression and Bcl-2 expression.conclusion (1) nm23 gene can suppress the metastasis of gastric adenocarcinoma.(2) The development (invasion and metastasis) of gastric adenocarcinoma is a result of tumor cellular constantly prolifer active potention and suppression of cellular apoptosis.