Correlation of p53 expression and angiogenesis in bone marrow biopsies of multiple myeloma

Objective To investigate the relationship among the expression of p53、vascular endothelial growth factor(VEGF) and angiogenesis in bone marrow biopsies of multiple myeloma. Methods The expression of VEGF、p53 and microvascular density(MVD) were examined by situ hybridization and immunohistochemical staining in bone marrow biopsies of 42 multiple myeloma patients. Results The positive expression rate of VEGF was 52.4%(22/42),the positive expression rate of p53 was 21.4%(9/42).Comparative study of the ser...