Antitumor Mechanism of Sodium Arsenic on Human Gastric Carcinoma Cell Line BGC-823 in Vitro

Objective To investigate the antitumor mechanism of sodium arsenic on human gastric carcinoma cell line BGC-823 in vitro. Methods MTT assay, light microscopy,electron microscopy,flow cytometry,and immunocytochemical staining were used to detect the effect of sodium arsenic on biologic behavior of BGC-823 cells. Results Sodium arsenic inhibited the growth of BGC-823 cells in a time and concentration dependent fashion,its 50% inhibitory concentration(IC_ 50 ) was 4.86μmol/L.BGC-823 cells were arrested significa...