K-ras and MTS1/p16 Gene Expression in Endometrial Carcinoma and Benign Endometrium and its Significance

Objective To discuss the relationship between K ras gene activation and MTS1/p16 gene mutation/deletion and the progression of endometrial carcinoma. Methods We determine the K ras protein and p16 protein in endometrial carcinoma and benign endometrium by immunohistochemistry, and determine the deletion of extronl of MTS1/p16 gene in endometrial carcinoma. Results The K ras protein and p16 protein extensively exist in endometrial carcinoma and benign endometrium. In benign endometrium K ras protein e...