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Effect of VEGF Antisense Oligonucleotide Combined with Low Molecular Weight Heparin on the Growth and Metastasis of Mice Bladder Cancer[J]. Cancer Research on Prevention and Treatment, 2007, 34(09): 663-666. DOI: 10.3971/j.issn.1000-8578.2534
Citation: Effect of VEGF Antisense Oligonucleotide Combined with Low Molecular Weight Heparin on the Growth and Metastasis of Mice Bladder Cancer[J]. Cancer Research on Prevention and Treatment, 2007, 34(09): 663-666. DOI: 10.3971/j.issn.1000-8578.2534
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Effect of VEGF Antisense Oligonucleotide Combined with Low Molecular Weight Heparin on the Growth and Metastasis of Mice Bladder Cancer

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  • Objective To investigate the inhibitory effect of vascular endothelial growth factor(VEGF) antisense oligonucleotides or/and dalteparin sodium(fragmin) on tumor growth and metastasis of mice bladder cancer. Methods Forty mice with bladder cancer were randomizedly divided into five groups:control group,VEGF antisense oligonucleotides(ASODN) group,VEGF mismatch sense oligonucleotides(MSODN) group,low molecular weight heparin (LMWH) group,and combined group.Sodium chloride,VEGF-ASODN,VEGF-MSODN,fragmin,and VEG...
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