Correlation between the Expressions of VEGF, bFGF and Some Apoptosis Proteins in Hapatocellular Carcinoma

Objective 　To explore the correlation between the expressions of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and some apoptosis proteins including Fas, bax, bcl-2 and bcl-xl in hepatocellular carcinoma ( HCC) . Methods 　Thirty2eight cases (40 lesions) of HCC verified by histopathology were studied. The expressions of VEGF, bFGF, Fas, bax, bcl-2 and bcl-xl were detected with immunohistochemical SP method, and the relationships among these proteins were analyzed. Results 　The positive rate of VEGF, bFGF, Fas, bax, bcl-2 and bcl-xl was 77. 5%(31/40), 75 %(30/40), 20 %(8/40), 25 %(10/40), 27. 5 %(11/40) and 50%(20/40) in HCC respectively. The positive correlations between VEGF and bFGF, bcl-2 and bcl-xl were found ( P < 0. 01 respectively) . The same results were also found between bax and bcl-2, VEGF and bcl2-2 、bax and bFGF ( P < 0. 05 respectively) . Conclusion 　The angiogenesis and cell apoptosis in HCC may be regulated by the expressions of VEGF, bFGF, Fas, bax, bcl-2 and bcl-xl.