Clinical Analysis of High Dose Rate Intraluminal After-loading Irradiation for Treatment of Mid-advanced Lung Cancer

Objective 　To analyze the therapeuticeffect of high dose rate int rluminal after-loading irradiation (ALI) plus extemal irradiation ( EI) on patients with mid-advanced lung cancer (MLC), and evaluate optimal total dose of and dosing schedule for ALI. Methods 　From June, 1993 to December 1997, we total treated of 61 MLC cases, in which 30 patients with high-dose fractionation ALI(A group) and 31 cases by low-dose fractionation ALI(B group) . The survival rate between two group was compared. Results 　The 1-3-5 year survival rate in A group was 56. 7 %, 26. 7 % and 16. 7 %respectively. While in B group, it was 64. 5 %, 45. 2 % and 29. 0 % respectively. Which was no significantly different ( P < 0. 05) . The complications had accrued rates in A group were much better than those in B group ( P > 0. 01) . Conclusion 　The therapeutic efect of B group is better than that of A group for MLC. It is safe and less side-effect . We conclude that 60～70 Gy of EI plus 20～30 Gy/ 4～6 times of ALI might be the optimal dose.