Molecular Biologic Characteristics and Relationship with Hepatocarcinogenesis of Oval Cells

CHEN Qiong-rong; XIANG Jing; LIU Qing-bo; ZHAO Guo-qiang; CHE Li-hong

doi:10.3971/j.issn.1000-8578.2337

Cancer Research on Prevention and Treatment > 2008 > 35(06): 390-393. > DOI: 10.3971/j.issn.1000-8578.2337

CHEN Qiong-rong, XIANG Jing, LIU Qing-bo, ZHAO Guo-qiang, CHE Li-hong. Molecular Biologic Characteristics and Relationship with Hepatocarcinogenesis of Oval Cells[J]. Cancer Research on Prevention and Treatment, 2008, 35(06): 390-393. DOI: 10.3971/j.issn.1000-8578.2337

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Molecular Biologic Characteristics and Relationship with Hepatocarcinogenesis of Oval Cells

1.Department of Pathology; Hubei Cancer Hospital; 430079 Wuhan; China; 2.Department of Pathology; The Affiliated Cancer Hospital of Sun Yat-sen University; 3.Department of Pathology; The First Affiliated Hospital of Sun Yat-sen University

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Corresponding author:
ZHAO Guo2qiang3
Received Date: October 31, 2007
Revised Date: February 27, 2008

Abstract

Abstract

Objective 　To detect the major biologic characteristics of oval cells, and to explore it s correla2 tion to hepatocarcinoma through dynamic observation on evolutive law of the oval cells in experimental hepatocarcinogenesis. Methods 　By const ructing the experimental liver cancer models and using tech2 niques including routine HE stain, alcian blue stain and immunohistochemist ry to observe the major bio2 logic characteristics of the oval cells and the law of evolution in hepatocarcinogenesis. Results 　Along with the prolonging of cancer2induction, the oval cells proliferated gradually, then come forth precancer2 ous lesions, and became hepatocellular and (or) cholangiocellular carcinoma. OV26, AFP and c2kit were expressed in all oval cells in every period. Conclusion 　Associated with abnormal differentiation of oval cells maybe associated with primary liver cancer, and the oval cells express OV26, AFP and c2kit charac2 teristically.
- Primary liver cancer,
- Oval cells,
- Biological characteristics,
- Hepatocarcinogenesis

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CHE Li-hong

1.Department of Pathology; Hubei Cancer Hospital; 430079 Wuhan; China; 2.Department of Pathology; The Affiliated Cancer Hospital of Sun Yat-sen University; 3.Department of Pathology; The First Affiliated Hospital of Sun Yat-sen University

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Molecular Biologic Characteristics and Relationship with Hepatocarcinogenesis of Oval Cells

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