Clinical Observation of Transdermal Fentanyl in Management of Nasopharyngeal Carcinoma Patients with Radiotheraputic Mucositis Pain

Objective 　To observe the clinical efficacy, the degree of improving life quality and adverse re2 action of Durogesic ( t ransdermal fentanyl) in management nasopharyngeal carcinoma patient s with mod2 erate or severe radiotheraputic mucositis pain in radiotherapy. Methods 　Sixty2six patient s with moderate or severe radiotheraputic mucositis pain were randomly divided into two groups : thirty2three patient s in t reatment group were t reated with both Durogesic and normal threapy, thirty2three patient s in cont rast group received normal threapy. The clinical efficacy, the degree of life quality and the side effect s during the radiotherapy were observed. Results 　In the t reatment group, the pain relief rate during the radiother2 apy was 88 %, and it is 33 % for cont rol group. The difference is significant ( P < 0. 01) between two groups. The life quality was obviously improved in t reatment group. The chief side effect was less. Con2 clusion 　Durogesic is effective for relieving pain and improving performance status of nasopharyngeal car2 cinoma patient s with moderate or severe radiotheraputic mucositis pain in radiotherapy. The adverse side effect s were less.