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LI Mei, ZHAO Bao-xia, YU Zhi-hong, LIU Min, FAN Kai, LV Shen. The Relationship of Mismatch Repair Proteins Expression to Drug Resistance of Gastrointestinal Tract[J]. Cancer Research on Prevention and Treatment, 2006, 33(07): 496-498. DOI: 10.3971/j.issn.1000-8578.2292
Citation: LI Mei, ZHAO Bao-xia, YU Zhi-hong, LIU Min, FAN Kai, LV Shen. The Relationship of Mismatch Repair Proteins Expression to Drug Resistance of Gastrointestinal Tract[J]. Cancer Research on Prevention and Treatment, 2006, 33(07): 496-498. DOI: 10.3971/j.issn.1000-8578.2292
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The Relationship of Mismatch Repair Proteins Expression to Drug Resistance of Gastrointestinal Tract

    Abstract
  • Objective To investigate the relationship of mismatch repair(MMR) proteins expression to drug resistance of gastrointestinal tract. Methods Immunohistochemistry and immunocytochemistry were used to detect the expressions of hMSH2 and hMLH1 in 5 gastric carcinomas,18 intestinal carcinomas and BGC823,BGC823/cDDP;MTT essay was used to detect the resistance of carcinoma tissues and the cell lines above to cDDP,5-Fu,VCR,MMC. Results The rates of hMSH2 in carcinoma tissues and their surrounding tissues were 74% and...
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