Sodium salicylate induced apoptosis in HL-60 cells and its relation to the changes of intracellular free Ca~(2+)

WAN You-feng; CHEN Xie-qun; BAI Qing-xian; et al

doi:10.3971/j.issn.1000-8578.2260

WAN You-feng, CHEN Xie-qun, BAI Qing-xian, et al. Sodium salicylate induced apoptosis in HL-60 cells and its relation to the changes of intracellular free Ca~(2+)[J]. Cancer Research on Prevention and Treatment, 2003, 30(04): 273-275. DOI: 10.3971/j.issn.1000-8578.2260

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Sodium salicylate induced apoptosis in HL-60 cells and its relation to the changes of intracellular free Ca~(2+)

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Objective To study the proapoptotic effect of Sodium Salicylate (Na-Sal) on the HL-60 Cells and its relation ship to the changes of intracellular free Ca 2+. Methods The phosphatidylserine exposure was measured by Annexin-V binding assay; DNA fragmentation detected by agarose gel electrophoresis; and the changes of the concentration of intracellular free Ca 2+ analyzed by confocal laser scanning microscope (CLSM). Results After treated with 5mmol/L(IC 50) Na-Sal for 10hs and 16hs, respectively,...

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Sodium salicylate induced apoptosis in HL-60 cells and its relation to the changes of intracellular free Ca~(2+)

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