Experimental Study on Inhibiting Angiogenesis in Tumor by Celastrol

Objective 　To investigate the effect of inhibiting angiogenesisby celastrol. Methods 　The tumor inhibitory rate and the vascular density were tested in animal tumor model with experimental t reatment . The expression of VEGF and bFGF were measured by immunohistochemist ry. Results 　The tumor inhibitory rate was 46. 86 % in celast rol (3mg/ kg), and was 60. 2 % in combined group . The int ratumoral microvessel density(MVD), expression of VEGF and bFGF in combined group and celastrol (3mg/ kg) group were lower than the cont rol and 5-Fu group ( P < 0. 01) . Conclusion 　Celast rol have inhibitory effect on S₁₈₀ sarcoma and strong inhibitory effects on angiogenesis. Its mechanism may be associated with the down-regulating of VEGF and bFGF expression.