Relationship between PCNA expression and apoptosis of human lung cancer cell line

Objective To investigate the relationship between proliferating cell nuclear antigen (PCNA) expression and apoptosis of human lung cancer cell line. Methods Arsenic trioxide (As_2O_3) was used to induce the direct apoptosis in human lung cancer GLC-82 cell line. The MTT method and flowcytometry (FCM) were used for detection. With RT-PCR, the changes and relations of PCNA in the process of GLC-82 apoptosis were studied. Results The data showed that As_2O_3 significatly. inhibited proliferation of GLC-82 ...