The Role of Collagen Ⅳ, Laminin and Fibronectin in Angiogenesis in Atypical Hyperplasia and Breast Carcinoma

Objective To investigate the role of collagen IV, Laminin and Fibronectin in angiogenesis in breast atypical hyperplasia and breast carcinoma. Methods The FⅧ related Antigen, Collagen Ⅳ, Laminin and Fibronectin were immunohistochemically stained in 10 normal breast, 17 simple hyperplasia, 18 mild atypical hyperplasia, 18 serious atypical hyperplasia as well as 25 breast carcinoma tissues, and Microvessel Endothelial Area(MEA), Microvessel Base Membrane Area(MBA) were quantitatively assessed by Computer Aided...