Expression of uPA, uPAR, nm23-H1 in Human Colorectal Cancer and Its Relation to Tumor Invasion and Metastasis

Objective To investigate the expression of urokinase type plasminogen activator(uPA), uPA receptor(uPAR) and nm23 H1 gene protein in human colorectal cancer and its relationship with the invasion and lymph node metastasis. Methods SABC immunohistochemical method was used to detect the uPA, uPAR and nm23 H1 gene protein expression in 121 cases with human colorectal cancer after the surgical treatment. Results The expression rate of uPA, uPAR and nm23 H1 in 121 cases were 62%, 74% and 48% respectively. A signif...