| Citation: |
WANG Jie, HOU Mingxing, CHENG Haidong, LIU Yongqiang, MIAO Jie, LI Shuwen, CHEN Lu. Application of Colorectal Cancer Early Screening Based on Multitarget Fecal FIT-DNA Joint Detection Technology[J]. Cancer Research on Prevention and Treatment, 2024, 51(7): 578-582. DOI: 10.3971/j.issn.1000-8578.2024.23.1364
|
To evaluate the efficacy and further analyze the application prospects of the combined multitarget fecal FIT-DNA assay in the early screening of colorectal cancer.
Subjects were selected from a population attending the Inner Mongolia Medical University Hospital. Each subject underwent a combined multi-target fecal FIT-DNA test (experimental group), a serum tumor marker test and enteroscopy (control group). The pathological results were used as the gold standard to evaluate the efficacy of novel fecal molecular testing techniques for colorectal cancer screening with timely intervention given to screen positive individuals.
The data of 115 individuals were analyzed. Serum tumor markers test had a sensitivity of 63.2% (43/68) and a specificity of 74.5% (35/47). The enteroscopy had a sensitivity of 97.1% (66/68) and a specificity of 80.7% (38/47); the combined multitarget fecal FIT-DNA test had a sensitivity of 89.7% (61/68) and a specificity of 87.2% (41/47).
The sensitivity and specificity of multitarget fecal FIT-DNA combined detection are better than those of serum tumor marker detection. Although its sensitivity is lower than enteroscopy, its operation is simpler and can be tested at home.
Competing interests: The authors declare that they have no competing interests.
| [1] |
Chen W, Sun K, Zheng R, et al. Cancer incidence and mortality in China, 2014[J]. Chin J Cancer Res, 2018, 30(1): 1-12. doi: 10.21147/j.issn.1000-9604.2018.01.01
|
| [2] |
Zheng RS, Zhang SW, Zeng HM, et al. Cancer incidence and mortality in China, 2016[J]. J Natl Cancer Cent, 2022, 2(1): 1-9. doi: 10.1016/j.jncc.2022.02.002
|
| [3] |
高静茹, 李佳昕, 乔友林, 等. 内蒙古地区中晚期结直肠癌患者的结直肠癌相关知识认知现状及影响因素研究[J]. 肿瘤防治研究, 2023, 50(6): 603-608. [Gao JR, Li JX, Qiao YL, et al. Cognition of Colorectal Cancer-related Knowledge and Influencing Factors of Patients with Middle-and Advanced-stage Colorectal Cancer in Inner Mongolia[J]. Zhong Liu Fang Zhi Yan Jiu, 2023, 50(6): 603-608.]
Gao JR, Li JX, Qiao YL, et al. Cognition of Colorectal Cancer-related Knowledge and Influencing Factors of Patients with Middle-and Advanced-stage Colorectal Cancer in Inner Mongolia[J]. Zhong Liu Fang Zhi Yan Jiu, 2023, 50(6): 603-608.
|
| [4] |
李晓, 马恒敏, 马学真, 等. 2014—2019年山东省青岛市城市居民结直肠癌早诊早治项目筛查结果分析[J]. 中国肿瘤, 2021, 30(5): 340-345. [Li X, Ma HM, Ma XZ, et al. Screening Results of Early Diagnosis and Treatment of Colorectal Cancer Among Urban Residents in Qingdao City from 2014 to 2019[J]. Zhongguo Zhong Liu, 2021, 30(5): 340-345.]
Li X, Ma HM, Ma XZ, et al. Screening Results of Early Diagnosis and Treatment of Colorectal Cancer Among Urban Residents in Qingdao City from 2014 to 2019[J]. Zhongguo Zhong Liu, 2021, 30(5): 340-345.
|
| [5] |
彭慧, 王巧燕, 黄芳, 等. 大肠癌筛查肠镜检查顺应性及影响因素研究[J]. 肿瘤预防与治疗, 2018, 31(5): 340-346. [Peng H, Wang QY, Huang F, et al. Compliance to Colonoscopy Screening in Patients with Colorectal Cancer and Its Impact Factors[J]. Zhong Liu Yu Fang Yu Zhi Liao, 2018, 31(5): 340-346.]
Peng H, Wang QY, Huang F, et al. Compliance to Colonoscopy Screening in Patients with Colorectal Cancer and Its Impact Factors[J]. Zhong Liu Yu Fang Yu Zhi Liao, 2018, 31(5): 340-346.
|
| [6] |
Buskermolen M, Cenin DR, Helsingen LM, et al. Colorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy: a microsimulation modelling study[J]. BMJ, 2019, 367: l5383.
|
| [7] |
金水, 王亚雷, 衡苗, 等. 粪便潜血试验及粪便DNA检测对结直肠癌筛查的比较研究[J]. 安徽医科大学学报, 2019, 54(9): 1485-1489. [Jin S, Wang YL, Heng M, et al. Comparison of the effectiveness of three fecal occult blood tests and digital immunoassay combined fecal DNA test on screening of colorectal cancer[J]. Anhui Yi Ke Da Xue Xue Bao, 2019, 54(9): 1485-1489.]
Jin S, Wang YL, Heng M, et al. Comparison of the effectiveness of three fecal occult blood tests and digital immunoassay combined fecal DNA test on screening of colorectal cancer[J]. Anhui Yi Ke Da Xue Xue Bao, 2019, 54(9): 1485-1489.
|
| [8] |
Ahlquist DA, Skoletsky JE, Boynton KA, et al. Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel[J]. Gastroenterology, 2000, 119(5): 1219-1227.
|
| [9] |
Zygulska AL, Pierzchalski P. Novel Diagnostic Biomarkers in Colorectal Cancer[J]. Int J Mol Sci, 2022, 23(2): 852. doi: 10.3390/ijms23020852
|
| [10] |
Carethers JM. Fecal DNA Testing for Colorectal Cancer Screening[J]. Annu Rev Med, 2020, 71: 59-69. doi: 10.1146/annurev-med-103018-123125
|
| [11] |
Piscitello A, Saoud L, Fendrick AM, et al. Estimating the impact of differential adherence on the comparative effectiveness of stool-based colorectal cancer screening using the CRC-AIM microsimulation model[J]. PLoS One, 2020, 15(12): e0244431. doi: 10.1371/journal.pone.0244431
|
| [12] |
Lamb YN, Dhillon S. Epi proColon® 2.0 CE: A Blood-Based Screening Test for Colorectal Cancer[J]. Mol Diagn Ther, 2017, 21(2): 225-232. doi: 10.1007/s40291-017-0259-y
|
| [13] |
Ridge JR, Statz S. Exact Sciences' experience with the FDA and CMS parallel review program[J]. Expert Rev Mol Diagn, 2015, 15(9): 1117-1124. doi: 10.1586/14737159.2015.1069184
|
| [14] |
国家卫生健康委员会医政司, 中华医学会肿瘤学分会. 中国结直肠癌诊疗规范(2023版)[J]. 中国实用外科杂志, 2023, 43(6): 602-630. [Department of Medicine, National Health Commission, Society of Oncology, Chinese Medical Association. Chinese guidelines for diagnosis and treatment of colorectal cancer (2023 edition)[J]. Zhongguo Shi Yong Wai Ke Za Zhi, 2023, 43(6): 602-630.]
Department of Medicine, National Health Commission, Society of Oncology, Chinese Medical Association. Chinese guidelines for diagnosis and treatment of colorectal cancer (2023 edition)[J]. Zhongguo Shi Yong Wai Ke Za Zhi, 2023, 43(6): 602-630.
|
| [15] |
祝悦, 徐志杰, 毛润越, 等. 中国基层卫生机构的恶性肿瘤筛查分析现状[J]. 肿瘤, 2019, 39(9): 756-761. [Zhu Y, Xu ZJ, Mao RY, et al. Current situation of cancer screening in primary health setting in China[J]. Zhong Liu, 2019, 39(9): 756-761.]
Zhu Y, Xu ZJ, Mao RY, et al. Current situation of cancer screening in primary health setting in China[J]. Zhong Liu, 2019, 39(9): 756-761.
|
| [16] |
孔庆周, 李延青. 结直肠癌和进展期腺瘤的早期诊断[J]. 胃肠病学, 2021, 26(10): 577-583. [Kong QZ, Li YQ. Early diagnosis of colorectal cancer and advanced adenoma[J]. Wei Chang Bing Xue, 2021, 26(10): 577-583.]
Kong QZ, Li YQ. Early diagnosis of colorectal cancer and advanced adenoma[J]. Wei Chang Bing Xue, 2021, 26(10): 577-583.
|
| [17] |
Benito L, Farre A, Binefa G, et al. Factors related to longitudinal adherence in colorectal cancer screening: qualitative research findings[J]. Cancer Causes Control, 2018, 29(1): 103-114. doi: 10.1007/s10552-017-0982-z
|
| [18] |
Wolf AMD, Fontham ETH, Church TR, et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society[J]. CA Cancer J Clin, 2018, 68(4): 250-281. doi: 10.3322/caac.21457
|
| [19] |
Provenzale D, Gupta S, Ahnen DJ, et al. NCCN Guidelines Insights: Colorectal Cancer Screening, Version 1. 2018[J]. J Natl Compr Canc Netw, 2018, 16(8): 939-949. doi: 10.6004/jnccn.2018.0067
|
| [20] |
中国抗癌协会大肠癌专业委员会中国结直肠肿瘤早诊筛查策略制订专家组. 中国结直肠肿瘤早诊筛查策略专家共识[J]. 中华胃肠外科杂志, 2018, 21(10): 1081-1086. [Chinese Colorectal Cancer Professional Committee, Chinese Colorectal Cancer Early Diagnosis Screening Strategy Expert Group. Expert Consensus on Early Diagnosis and Screening Strategies for Colorectal Tumors in China[J]. Zhonghua Wei Chang Wai Ke Za Zhi, 2018, 21(10): 1081-1086.]
Chinese Colorectal Cancer Professional Committee, Chinese Colorectal Cancer Early Diagnosis Screening Strategy Expert Group. Expert Consensus on Early Diagnosis and Screening Strategies for Colorectal Tumors in China[J]. Zhonghua Wei Chang Wai Ke Za Zhi, 2018, 21(10): 1081-1086.
|
| [21] |
Gao Y, Wang J, Zhou Y, et al. Evaluation of Serum CEA, CA19-9, CA72-4, CA125 and Ferritin as Diagnostic Markers and Factors of Clinical Parameters for Colorectal Cancer[J]. Sci Rep, 2018, 8(1): 2732. doi: 10.1038/s41598-018-21048-y
|
| [22] |
马晨曦, 关旭, 王松, 等. 粪便DNA检测技术在结直肠癌筛查中的应用现状及展望[J]. 中华胃肠外科杂志, 2019, 22(5): 491-494. [Ma CX, Guan X, Wang S, et al. Application and prospect of fecal DNA test in colorectal cancer screening[J]. Zhonghua Wei Chang Wai Ke Za Zhi, 2019, 22(5): 491-494.]
Ma CX, Guan X, Wang S, et al. Application and prospect of fecal DNA test in colorectal cancer screening[J]. Zhonghua Wei Chang Wai Ke Za Zhi, 2019, 22(5): 491-494.
|
Tables(4)
This work is licensed under a Creative Commons Attribution 3.0 License.
Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号
Supported by: Beijing Renhe Information Technology Co., Ltd. 
DownLoad: