Advances on Clinical Application of Adaptive Radiotherapy in Treatment of Nasopharyngeal Carcinoma

ZHANG Yucong; XU Gang

doi:10.3971/j.issn.1000-8578.2023.22.1419

Cancer Research on Prevention and Treatment > 2023 > 50(4): 422-426. > DOI: 10.3971/j.issn.1000-8578.2023.22.1419

ZHANG Yucong, XU Gang. Advances on Clinical Application of Adaptive Radiotherapy in Treatment of Nasopharyngeal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2023, 50(4): 422-426. DOI: 10.3971/j.issn.1000-8578.2023.22.1419

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Advances on Clinical Application of Adaptive Radiotherapy in Treatment of Nasopharyngeal Carcinoma

ZHANG Yucong,
XU Gang^, ,

The Second Clinical Medical College, Jinan University, Shenzhen 518020, China

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Corresponding author:
XU gang, E-mail: sy2363@126.com
Received Date: November 28, 2022
Revised Date: February 11, 2023
Available Online: January 12, 2024

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Abstract

Abstract

Radiotherapy is the first treatment choice for nasopharyngeal carcinoma. With the rapid development of image-guided radiotherapy, adaptive radiotherapy (ART) has become widely available in clinical practice. ART may be implemented to monitor the anatomical or physiological variations of patients using dynamic imaging technology and feedback information during the treatment course, including geometric changes (size, shape, and position) of tumor and normal organs. ART also allows the modification of the treatment plan to accurately deliver the maximize dose to target and minimize normal tissue explosion. This review discusses the physics basis of ART and its state-of-art application and potential pitfalls.
- Nasopharyngeal carcinoma,
- Adaptive radiotherapy,
- Imaging-guided,
- Re-plan

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Competing interests: The authors declare that they have no competing interests.

References (34)

References

[1]	Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249. doi: 10.3322/caac.21660
[2]	Lee AW, Ng WT, Chan YH, et al. The battle against nasopharyngeal cancer[J]. Radiother Oncol, 2012, 104(3): 272-278. doi: 10.1016/j.radonc.2012.08.001
[3]	Lee AW, Ng WT, Chan LL, et al. Evolution of treatment for nasopharyngeal cancer-success and setback in the intensity-modulated radiotherapy era[J]. Radiother Oncol, 2014, 110(3): 377-384. doi: 10.1016/j.radonc.2014.02.003
[4]	Yan D. Adaptive radiotherapy: merging principle into clinical practice[J]. Semin Radiat Oncol, 2010, 20(2): 79-83. doi: 10.1016/j.semradonc.2009.11.001
[5]	Sonke JJ, Aznar M, Rasch C. Adaptive Radiotherapy for Anatomical Changes[J]. Semin Radiat Oncol, 2019, 29(3): 245-257. doi: 10.1016/j.semradonc.2019.02.007
[6]	Briens A, Castelli J, Barateau A, et al. Adaptive radiotherapy: Strategies and benefits depending on tumor localization[J]. Cancer Radiother, 2019, 23(6-7): 592-608. doi: 10.1016/j.canrad.2019.07.135
[7]	Belshaw L, Agnew CE, Irvine DM, et al. Adaptive radiotherapy for head and neck cancer reduces the requirement for rescans during treatment duo to spinal cord dose[J]. Radiat Oncol, 2019, 14(1): 189. doi: 10.1186/s13014-019-1400-3
[8]	Tan W, Li Y, Han G, et al. Target volume and position variations during intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma[J]. Onco Targets Ther, 2013, 6: 1719-1728.
[9]	Tan W, Yang M, Sheng W, et al. Geometric Variations of the Clinical Target Volume in Neck Sublocations for Image-Guided Radiation Therapy of Nasopharyngeal Cancer[J]. Int J Radiat Oncol Biol Phys, 2018, 102(3S): e354.
[10]	Hend D, Menjja W, Fourat N, et al. Adaptive radiotherapy for nasopharyngeal carcinomas: Where are we?[J]. Bull Cancer, 2022, 105(5): 565-573.
[11]	Yang H, Hu W, Wang W, et al. Replanning during intensity modulated radiation therapy improved quality of life in patients with nasopharyngeal carcinoma[J]. Int J Radiat Oncol Biol Phys, 2013, 85(1): e47-e54. doi: 10.1016/j.ijrobp.2012.09.033
[12]	Weppler S, Quon H, Schinkel C, et al. Patient-Reported Outcomes-Guided Adaptive Radiation Therapy for Head and Neck Cancer[J]. Front Oncol, 2021, 11: 759724. doi: 10.3389/fonc.2021.759724
[13]	Avgousti R, Antypas C, Armpilia C, et al. Adaptive radiation therapy: When, how and what are the benefits that literature provides?[J]. Cancer Radiother, 2022, 26(4): 622-636. doi: 10.1016/j.canrad.2021.08.023
[14]	Gensheimer MF, Le QT. Adaptive radiotherapy for head and neck cancer: Are we ready to put it into routine clinical practice?[J]. Oral Oncol, 2018, 86: 19-24. doi: 10.1016/j.oraloncology.2018.08.010
[15]	Veresezan O, Troussier I, Lacout A, et al. Adaptive radiation therapy in head and neck cancer for clinical practice: state of the art and practical challenges[J]. Jpn J Radiol, 2017, 35(2): 43-52. doi: 10.1007/s11604-016-0604-9
[16]	Yang H, Hu W, Ding W, et al. Changes of the transverse diameter and volume and dosimetry before the 25th fraction during the course of intensity-modulated radiation therapy (IMRT) for patients with nasopharyngeal carcinoma[J]. Med Dosim, 2012, 37(2): 225-229. doi: 10.1016/j.meddos.2011.08.003
[17]	Wang W, Yang H, Hu W, et al. Clinical study of the necessity of replanning before the 25th fraction during the course of intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma[J]. Int J Radiat Oncol Biol Phys, 2010, 77(2): 617-621. doi: 10.1016/j.ijrobp.2009.08.036
[18]	Tan W, Ye J, Xu R, et al. The tumor shape changes of nasopharyngeal cancer during chemoradiotherapy: the estimated margin to cover the geometrical variation[J]. Quant Imaging Med Surg, 2016, 6(2): 115-124. doi: 10.21037/qims.2016.03.07
[19]	Brock KK. Adaptive radiotherapy: Moving into the future[J]. Semin Radiat Oncol, 2019, 29(3): 181-184. doi: 10.1016/j.semradonc.2019.02.011
[20]	Talbot A, Devos L, Dubus F, et al. Multimodel imaging in radiotherapy: Focus on adaptive therapy and quality control[J]. Cancer Radiother, 2020, 24(5): 411-417. doi: 10.1016/j.canrad.2020.04.007
[21]	Hansen EK, Bucci MK, Quivey JM, et al. Repeat CT imaging and replanning during the course of IMRT for head-and-neck cancer[J]. Int J Radiat Oncol Biol Phys, 2006, 64(2): 355-362. doi: 10.1016/j.ijrobp.2005.07.957
[22]	Wu Q, Chi Y, Chen PY, et al. Martinez A. Adaptive replanning strategies accounting for shrinkage in head and neck IMRT[J]. Int J Radiat Oncol Biol Phys, 2009, 75(3): 924-932. doi: 10.1016/j.ijrobp.2009.04.047
[23]	张祥斌, 李光俊, 张英杰, 等. 剂量引导放疗的临床应用及研究进展[J]. 中华放射肿瘤学杂志, 2020, 29(1): 65-68. doi: 10.3760/cma.j.issn.1004-4221.2020.01.015 Zhang XB, Li GJ, Zhang YJ, et al. Clinical application and research progress on dose-guided radiotherapy[J]. Zhonghua Fang She Zhong Liu Xue Za Zhi, 2020, 29(1): 65-68. doi: 10.3760/cma.j.issn.1004-4221.2020.01.015
[24]	谭文勇, 邱大胜. MRI在放射治疗中的应用进展[J]. 中华临床医师杂志(电子版), 2015, 9(6): 1031-1035. doi: 10.3877/cma.j.issn.1674-0785.2015.06.033 Tan WY, Qiu DS. Advances of magenatic resonance imaging in radiation therapy[J]. Zhonghua Lin Chuang Yi Shi Za Zhi (Dian Zi Ban), 2015, 9(6): 1031-1035. doi: 10.3877/cma.j.issn.1674-0785.2015.06.033
[25]	Glide-Hurst CK, Lee P, York AD, et al. Adaptive radiation therapy (ART) strategies and technical considerations: A state of the ART review from NRG oncology[J]. Int J Radiat Oncol Biol Phys, 2021, 109(4): 1054-1075. doi: 10.1016/j.ijrobp.2020.10.021
[26]	Hvid CA, Elstrøm UV, Jensen K, et al. Cone-beam computed tomography (CBCT) for adaptive image guided head and neck radiation therapy[J]. Acta Oncol, 2018, 57(4): 552-556. doi: 10.1080/0284186X.2017.1398414
[27]	Liu Q, Liang J, Zhou D, et al. Dosimetric Evaluation of Incorporating Patient Geometric Variations Into Adaptive Plan Optimization Through Probabilistic Treatment Planning in Head and Neck Cancers[J]. Int J Radiat Oncol Biol Phys, 2018, 101(4): 985-997. doi: 10.1016/j.ijrobp.2018.03.062
[28]	Pigorsch SU, Kampfer S, Oechsner M, et al. Report on planning comparison of VMAT, IMRT and helical tomotherapy for the ESCALOX-trial pre-study[J]. Radiat Oncol, 2020, 15(1): 253. doi: 10.1186/s13014-020-01693-2
[29]	武星蕾, 吴爱东, 吴爱林. 准直器角度对鼻咽癌容积旋转调强计划及剂量验证的影响[J]. 中国医学物理学杂志, 2019, 36(11): 1249-1254. doi: 10.3969/j.issn.1005-202X.2019.11.002 Wu XL, Wu AD, Wu AL. Effect of collimator angels on planning and dose verification of volumetric modulated arc therapy for nasopharyngeal carcinoma[J]. Zhongguo Yi Xue Wu Li Xue Za Zhi, 2019, 36(11): 1249-1254. doi: 10.3969/j.issn.1005-202X.2019.11.002
[30]	Grégoire V, Langendijk JA, Nuyts S. Advances in Radiotherapy for Head and Neck Cancer[J]. J Clin Oncol, 2015, 33(29): 3277-3284. doi: 10.1200/JCO.2015.61.2994
[31]	Green OL, Henke LE, Hugo GD. Practical Clinical Workflows for Online and Offline Adaptive Radiation Therapy[J]. Semin Radiat Oncol, 2019, 29(3): 219-227. doi: 10.1016/j.semradonc.2019.02.004
[32]	Eraj S, Sher DJ. PET/CT: Radiation Therapy Planning in Head and Neck Cancer[J]. PET Clin, 2022, 17(2): 297-305. doi: 10.1016/j.cpet.2021.12.007
[33]	Chandra RA, Keane FK, Voncken FEM, et al. Contemporary radiotherapy: present and future[J]. Lancet, 2021, 398(10295): 171-184. doi: 10.1016/S0140-6736(21)00233-6
[34]	Wong KCW, Hui EP, Lo KW, et al. Nasopharyngeal carcinoma: an evolving paradigm[J]. Nat Rev Clin Oncol, 2021, 18(11): 679-695. doi: 10.1038/s41571-021-00524-x

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Advances on Clinical Application of Adaptive Radiotherapy in Treatment of Nasopharyngeal Carcinoma