Effect of Photodynamic Therapy for Malignant Obstruction of Biliary Tract

YU Jian'an; SU Tianhao; LI Jian; YANG Siwei; WEI Jian; JIN Long

doi:10.3971/j.issn.1000-8578.2023.22.0951

Cancer Research on Prevention and Treatment > 2023 > 50(4): 397-400. > DOI: 10.3971/j.issn.1000-8578.2023.22.0951

YU Jian'an, SU Tianhao, LI Jian, YANG Siwei, WEI Jian, JIN Long. Effect of Photodynamic Therapy for Malignant Obstruction of Biliary Tract[J]. Cancer Research on Prevention and Treatment, 2023, 50(4): 397-400. DOI: 10.3971/j.issn.1000-8578.2023.22.0951

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Effect of Photodynamic Therapy for Malignant Obstruction of Biliary Tract

Department of Interventional Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

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Corresponding author:
JIN Long, E-mail: longerg@hotmail.com
Received Date: August 21, 2022
Revised Date: December 20, 2022
Available Online: January 12, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the safety and efficacy of photodynamic therapy (PDT) for malignant obstruction of the biliary tract.
Methods
We retrospectively analyzed the clinical data of patients with malignant biliary obstruction treated by PDT in our medical center. On the basis of different treatment plans, the patients were categorized into the photodynamic only group and the combined treatment group, in which additional interventional operations, targeted therapy, or immunotherapy were arranged. The alterations in liver function, duration of biliary patency, and postoperative complications that occurred within one month were closely monitored in both groups.
Results
A total number of 19 patients were enrolled in this study. The technical success rate of PDT was 100%. The deterioration of liver function was not observed in any patients within one month after PDT. Within a maximum of 17.7 months follow-up, the patency rates of the biliary tract were 100.0%, 89.5%, 72%, and 64% at 1, 3, 6, and 12 months after the procedure, respectively. The mean biliary patency time was 6.9±0.8 months (95%CI: 5.2-8.7 months). Specifically, the biliary patency times for Bismuth type Ⅲ and Ⅳ were 7.5±1.1 and 6.1±1.3 months, respectively. The biliary patency time was around 3.3±0.7 months in the photodynamic only group and 7.9±0.9 months in the combined treatment group (P=0.017).
Conclusion
PDT for Bismuth Ⅲ-Ⅳ malignant biliary obstruction is safe and effective. Moreover, the period of biliary patency is greatly extended when PDT is combined with systemic therapy.
- Photodynamic therapy,
- Biliary stricture,
- Cholangiocarcinoma,
- Biliary obstruction,
- Obstructive jaundice

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Competing interests: The authors declare that they have no competing interests.

References (24)

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Effect of Photodynamic Therapy for Malignant Obstruction of Biliary Tract