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LIANG Cuilyu, ZHANG Yin, CHEN Qiying, ZHUO Pingping. Efficacy of Multiple Drugs in Preventing Chronic Peripheral Neuropathy Induced by Platinum and Taxane: A Network Meta-analysis[J]. Cancer Research on Prevention and Treatment, 2022, 49(2): 128-140. DOI: 10.3971/j.issn.1000-8578.2022.21.0675
Citation: LIANG Cuilyu, ZHANG Yin, CHEN Qiying, ZHUO Pingping. Efficacy of Multiple Drugs in Preventing Chronic Peripheral Neuropathy Induced by Platinum and Taxane: A Network Meta-analysis[J]. Cancer Research on Prevention and Treatment, 2022, 49(2): 128-140. DOI: 10.3971/j.issn.1000-8578.2022.21.0675
shu

Efficacy of Multiple Drugs in Preventing Chronic Peripheral Neuropathy Induced by Platinum and Taxane: A Network Meta-analysis

  • 1.

    Department of Pharmacy, Second Affiliated Hospital, Fujian Medical University, Quanzhou 362000, China

  • 2.

    Second Clinical Medicine College, Fujian Medical University, Quanzhou 362000, China

Funding: 

Quanzhou High Level Talent Project for 2017 2017Z012

More Information
  • Corresponding author:

    ZHANG Yin, E-mail: zyin1973@163.com

  • Received Date: June 10, 2021
  • Revised Date: November 29, 2021
  • Available Online: January 12, 2024
    Graphical Abstract
    • Abstract
  • Objective 

    To perform a network meta-analysis (NMA) for the efficacy of 11 drugs in preventing chronic peripheral neuropathy induced by platinum and taxane (PTIPN).

    Methods 

    PubMed, Cochrane library, Embase, CNKI, WanFang database and VIP database were searched up to February 2021 for relevant randomized controlled trials (RCTs) addressing the drugs to prevent PTIPN. After extracting relevant data, Stata 14.0 and ADDIS 1.16.6 softwares were used for statistical analysis.

    Results 

    A total of 70 studies involving 6201 patients were included. The results of network Meta-analysis showed that amifostine, ganglioside, Huangqi Guizhi Wuwu decoction (HQGZT), vitamin E, calcium and magnesium infusion and omega-3 fatty acids were superior to placebo or blank groups in reducing the incidence of overall or severe PTIPN. The rank probability plot and the SUCRA calculation results suggested that amifostine, HQGZT and omega-3 fatty acids were in first order. The differences between the 11 drugs and placebo or blank groups were not statistically significant, except for amifostine which was reported to aggravate the adverse reactions of nausea and vomiting and hypotension in patients.

    Conclusion 

    HQGZT, Ganglioside, Vitamin E, omega-3 fatty acids, calcium and magnesium infusion and glutathione can reduce the occurrence of PTIPN, and HQGZT has the highest efficiency.

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  • Competing interests: The authors declare that they have no competing interests.

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