Effect of Short-term Complications After D2 Radical Gastrectomy on Long-term Survival Rate of Gastric Cancer Patients

LIN Penghang; LIN Chunlin; WANG Qin; HE Ruofan; CHEN Hui; HUANG Yongjian; YANG Shugang; YE Jianxin; ZHU Guangwei

doi:10.3971/j.issn.1000-8578.2021.20.1390

Cancer Research on Prevention and Treatment > 2021 > 48(6): 625-630. > DOI: 10.3971/j.issn.1000-8578.2021.20.1390

LIN Penghang, LIN Chunlin, WANG Qin, HE Ruofan, CHEN Hui, HUANG Yongjian, YANG Shugang, YE Jianxin, ZHU Guangwei. Effect of Short-term Complications After D2 Radical Gastrectomy on Long-term Survival Rate of Gastric Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2021, 48(6): 625-630. DOI: 10.3971/j.issn.1000-8578.2021.20.1390

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Effect of Short-term Complications After D2 Radical Gastrectomy on Long-term Survival Rate of Gastric Cancer Patients

LIN Penghang¹,
LIN Chunlin^{1, *},
WANG Qin^{1, 2},
HE Ruofan^{1, 2},
CHEN Hui^{1, 2},
HUANG Yongjian¹,
YANG Shugang¹,
YE Jianxin¹,
ZHU Guangwei^1, ,

1.
Department of Gastrointestinal Surgery 2 Section, The First Hospital Affiliated to Fujian Medical University, Institute of Abdominal Surgery, Key Laboratory of Accurate Diagnosis and Treatment of Cancer, Fuzhou 350005, China
2.
Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350005, China

Funding:

National Natural Science Foundation 81702424

National Natural Science Foundation 81872364

Natural Science Foundation of Fujian Science and Technology Department 2018J05127

Fujian Health and Health Commission Young and Middle-aged Backbone Project Funding Project 2018-ZQN-46

National Health and Health Commission Clinical Key Specialist Construction Project (General Surgery) Project 2013

More Information

Corresponding author:
ZHU Guangwei, E-mail: zgwzsy@126.com
^*: Contributed Equally as the First Author
Received Date: November 26, 2020
Revised Date: February 07, 2021
Available Online: January 12, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the effect of short-term complications after D2 radical gastrectomy on long-term survival rate of gastric cancer patients.
Methods
A retrospective case-control study was conducted on 421 patients with gastric cancer who underwent D2 radical gastrectomy. According to the short-term postoperative complications, they were divided into experimental group (complication group, n=76) and control group (without complication group, n=345). In order to reduce the selection bias, the long-term survival rate of the two groups was tested by Kaplan-Meier survival analysis method after balancing the variables by propensity score matching (PSM). Log rank method was used for univariate analysis and Cox multivariate analysis was used for prognostic factors.
Results
There was no significant difference in long-term survival rate between the experimental group and the control group (P > 0.05). Histological type, lymph node metastasis rate and pTNM stage were independent risk factors for long-term survival.
Conclusion
The short-term complications after D2 radical gastrectomy have no significant impact on the long-term survival rate of gastric cancer patients, but it has certain clinical significance to actively prevent and control complications.

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Competing interests: The authors declare that they have no competing interests.

References (16)

References

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Effect of Short-term Complications After D2 Radical Gastrectomy on Long-term Survival Rate of Gastric Cancer Patients