Neuropilin-1 Expression in Treg and PDC Cells in Peripheral Blood of Non-small Cell Lung Cancer Patients and Clinical Significance

Objective  To investigate Neuropilin-1 expression in Treg and PDC cells in peripheral blood of non-small cell lung cancer patients and clinical significance.

Methods  We collected the peripheral blood of 49 diagnosed non-small cell lung cancer patients, and 33 healthy subjects were taken as control group. The expression of NRP-1 on Treg and PDC cells in peripheral blood were detected by flow cytometry.

Results  The expression rate of NRP-1 in Treg cells of NSCLC patients was significantly higher than that of healthy subjects (P < 0.05). The expression of NRP-1 in Treg cells of NSCLC patients was correlated with the maximum diameter of tumor, lymph node metastasis, TNM stage and differentiation degree (P < 0.05); the expression of PDC was related to the maximum diameter of the tumor, lymph node metastasis and TNM staging(P < 0.05).

Conclusion  The expression of NRP-1 in peripheral blood Treg and PDC cells may be associated with immunoregulation of non-small cell lung cancer. It may be a tumor marker for predicting the prognosis of NSCLC patients, and a new target for lung cancer treatment.