Objective To investigate the correlation of three CLDN23 SNPs with the hereditary susceptibility and prognosis of gastric carcinoma in Han nationality in Fujian.
Methods Three SNP loci genotypes (rs12153, rs1060106 and rs11249884) of CLDN23 gene were detected using PCR-LDR method.
Results There was no significant difference in genotypes and allele frequencies of CLDN23 SNP rs12153, rs1060106 and rs11249884 between the gastric carcinoma group and the control group(P > 0.05). The frequency of genotype distribution in these three loci of the gastric cancer group was significantly correlated with tumor differentiation and pT staging(P < 0.05). The genotype distribution frequencies of rs12153 and rs1060106 were significantly correlated with post-operative survival time of the patients(P < 0.05). Among rs12153, rs1060106 and rs11249884, linkage disequilibrium of CLDN23 gene was absent. There was significant difference of C-T-G haplotype distribution between the gastric carcinoma group and the control group(P < 0.01).
Conclusion The polymorphisms of CLDN23 SNP rs12153, rs1060106 and rs11249884 are associated with tumor differentiation and pT staging, suggesting their possible role in the progression of gastric carcinoma in Han nationality in Fujian. The polymorphisms of rs12153 and rs1060106 are correlated with the prognosis of gastric cancer patients.
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