| Citation: |
SONG Jinling, LI Zhongwu, WEI Maomao, ZHOU Ni'na, YANG Zhi, WANG Xuejuan. Relation Between Metabolic Parameters of 18F-FDG PET/CT and Clinicopathological Features of Colorectal Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2019, 46(11): 1006-1012. DOI: 10.3971/j.issn.1000-8578.2019.19.0665
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To investigate the relation between 18F-FDG PET/CT metabolic parameters and the clinicopathological characteristics of colorectal cancer (CRC) patients.
We included 358 CRC patients who met the admission criteria. 18F-FDG PET/CT scans were performed before any treatment. Maximum standard uptake, average standard uptake, tumor metabolic volume (MTV) and total glycolysis (TLG) of the primary lesion of CRC were measured and calculated. The correlation of metabolic parameters with lesion location, pathological profile and TNM staging were investigated through Mann-Whitney U test and Kruskal-Wallis test.
The MTV and TLG values in the primary foci of colon cancer were the highest, followed by sigmoid cancer and the lowest in rectal cancer, with statistically significant differences between the groups (P < 0.001). SUVmax values of poorly/poorly-moderately differentiated colorectal cancer were higher than those of moderately/well differentiated colorectal cancer (P=0.028). MTV values of primary mucinous adenocarcinoma were higher than those of primary adenocarcinoma (P=0.023). MTV and TLG values were higher in T4 lesions than those in T2-3 lesions (P=0.0001, P=0.007); SUVmax and SUVmean values of sigmoid carcinoma with distant metastasis were lower than those without distant metastasis(P=0.015, P=0.011).
The metabolic parameters of CRC are correlated with the lesion location, pathological features and TNM staging, which could partly reflect the pathological characteristics and heterogeneity of CRC.
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