| Citation: |
LUO Binrui, GUO Tianhong, HUANG Yuanshuai. Diagnostic Values of Salivary miRNA-21 for Early Laryngeal Squamous Cell Carcinoma[J]. Cancer Research on Prevention and Treatment, 2018, 45(5): 320-325. DOI: 10.3971/j.issn.1000-8578.2018.17.1137
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To explore the diagnostic value of salivary miR-21 for patients with laryngeal squamous cell carcinoma(LSCC).
We collected saliva samples from 20 LSCC patients, 15 vocal cord polyp patients and 15 healthy controls were collected. Real-time quantitative reverse transcription PCR was applied to compare the relative expression of miR-21. The changes of miRNA-21 in six LSCC patients before and six months after operation was compared through monitoring analysis.
The expression of salivary miRNA-21 in LSCC patients was significantly higher than that in healthy control group (P=0.036). The diagnostic value of miRNA-21 for LSCC by ROC curve analysis showed that the area under the curve (AUC) of the miRNA-21 in saliva was 0.792 (95%CI: 0.5353-0.885, P=0.036). The relative expression level of miRNA-21 was significantly decreased in six LSCC patients beforeand six months after operation(P=0.041).
miRNA-21 is highly expressed in the saliva of patients with laryngeal squamous cell carcinoma, and it could be used as an indicator of early diagnosis of laryngeal squamous cell carcinoma in future.
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