Apoptosis Induction of Lycorine on Lung Cancer NCI-H460 Cells and Related Mechanism

LI Juwei; YANG Yang

doi:10.3971/j.issn.1000-8578.2018.17.0388

LI Juwei, YANG Yang. Apoptosis Induction of Lycorine on Lung Cancer NCI-H460 Cells and Related Mechanism[J]. Cancer Research on Prevention and Treatment, 2018, 45(1): 5-8. DOI: 10.3971/j.issn.1000-8578.2018.17.0388

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Apoptosis Induction of Lycorine on Lung Cancer NCI-H460 Cells and Related Mechanism

LI Juwei,
YANG Yang

Abstract

Abstract

Objective To investigate the effect of lycorine on the proliferation inhibition and apoptosis induction in human lung cancer NCI-H460 cells, and to explore the anti-tumor mechanism of lycorine.
Methods MTT assay was used to detect the proliferation of NCI-H460 cells. The apoptosis rate of NCI-H460 cells was detected by flow cytometry. The activity of Caspase 3 was detected by colorimetry.
Results Lycorine could inhibit the proliferation of NCI-H460 cells, and the IC₅₀ was (5.79±0.11)μmol/L. Lycorine had an induced effect on the apoptosis of NCI-H460 cells. Lycorine could enhance Caspase 3 activity.
Conclusion Lycorine could effectively inhibit the proliferation and induce the apoptosis of NCI-H460 cells in vitro, and its mechanism may be related to the activation of Caspase 3 expression and the apoptosis induce of tumor cells.

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Apoptosis Induction of Lycorine on Lung Cancer NCI-H460 Cells and Related Mechanism

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