Research Progress on Efficacy of Aerobic Exercise Training on Tumor Microenvironment

In recent years, exercise has been demonstrated to play an important role in the genesis and progression of tumor as a non-drug treatment. There has been an increased interest in the regular exercise training as adjunctive therapy of cancer. As the survival places of tumor cells, tumor microenvironment also plays a crucial role in tumor progress. In order to introduce exercise as a candidate treatment in cancer control, clarifying the mechanism by which exercise affects tumor microenvironment is required. This review summarizes the advances in the mechanism of aerobic exercise in hypoxia, tumor-associated macrophages and chronic inflammation responses of tumor microenvironment.