Objective To evaluate the effect of surgery on spinal cord function, physical status and pain of the patients with spinal metastatic tumor and spinal cord neoplastic score (SINS)≥7 points.
Methods A number of 115 spinal metastatic carcinoma patients with SINS≥7 points, expected survival > 6 months and ECOG score≤3 were included in this study. According to whether or not they had received spinal surgery, the patients were divided into surgery group and non-surgery group. The spinal cord function, physical status and bone metastasis-related pain of the patients were evaluated respectively. In surgery group, the evaluation was performed within one week before surgery and 6 months after surgery. In non-surgery group, the first evaluation was the time when patients were firstly identified SINS score≥7 points and the second evaluation was six months after that.
Results At the first evaluation, spinal cord function (P=0.033) and physical condition (P=0.007) in the surgery group were significantly lower than those in the non-surgery group, and the degree of pain was more intense than that in the non-surgery group (P=0.029). In the second evaluation, spinal cord function and physical condition in the surgery group were significantly better than those in the non-surgery group (both P < 0.001), and the pain degree was not signific antly different between the two groups (P=0.088).
Conclusion For the patients with spinal metastatic carcinoma and SINS score≥7, surgical treatment can effectively protect spinal cord function, relieve pain, maintain physical status, preserve and improve the quality of life.
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