Expression of IRSp53 in Epithelial Ovarian Carcinoma and Its Prognostic Significance

Objective To analyse the IRSp53 expression and its prognostic significance in epithelial ovarian carcinoma tissues.

Methods The expressions of IRSp53 in 76 cases of epithelial ovarian carcinoma were detected by SP immunohistochemical technique. The relationship between the IRSp53 expression and the clinical pathological characteristics and the pathological grading of the patients was analyzed. The prognostic significance of IRSp53 in epithelial ovarian carcinoma was discussed.

Results The expression of IRSp53 was significantly correlated with FIGO stage (Z=-3.526, P < 0.05), histopathological grading (Z=-2.471, P < 0.05), pathologic type (Z=-2.305, P < 0.05), lymph node metastasis (Z=1.124, P < 0.05) and CA125 level (Z=1.462, P < 0.05). There was a positive correlation between the expression intensity of IRSp53 and pathological grade (r=0.779, P < 0.05). The 5-year cumulative survival rate of the patients with low IRSp53 expression was significantly higher than that with high IRSp53 expression (χ² =5.018, P < 0.05).

Conclusion IRSp53 plays an important role in the development of epithelial ovarian carcinoma, and the over-expression of IRSp53 may lead to poor prognosis.