Expression and Significance of HPV16/18 Protein in Prostate Cancer Tissues

Objective To investigate the expression of HPV16/18 in human prostate cancer tissues and its relationship with clinicopathological parameters.

Methods The expressions of HPV16/18 were detected by immunohistochemistry in 86 cases of prostatic adenocarcinoma tissues and 80 cases of benign prostatic hyperplasia tissues.

Results The positive expression rates of HPV16/18 in the prostate cancer group and the benign prostatic hyperplasia group were 22.58% and 11.25%, respectively(P=0.018). In the prostate cancer group, there were certain relationship of HPV16/18 expression with Gleason score and clinical stage(all P<0.05), while no relationship with PSA levels, vascular invasion, lymph node metastasis or distant metastasis(all P>0.05).

Conclusion There is a certain relationship between HPV16/18 and the occurrence and development of prostate cancer, which may be one of the biological indicators for early diagnosis and treatment of prostate cancer.