Investigation of Dynamic Constituent Ratio Changes of Lung Cancer in Ningxia, 2000-2014

To analyze the constituent ratio changes of lung cancer and part of the epidemiological characteristics.

We collected the clinical data of the patients who have been diagnosed as lung cancer by histopathology or cytology in the General Hospital of Ningxia Medical University from January,2000 to December,2014. And we analyzed the constituent ratio changes of central lung cancer(CLC) and peripheral lung cancer(PLC),changes of different pathological types and changes of gender,age and smoking status.

There were 3 608 cases of lung cancer diagnosed,including 2 081(57.68%) cases of CLCs and 1 527 (42.32%) cases of PLCs. The proportion of CLCs had decreased gradually(P=0.000) but PLCs had presented a rising tendency (P=0.000) . Including 1 328(46.13%）cases of squamous cell carcinomas(SCC) and 1 511(52.48%) cases of adenocarcinoma (AD). but SCC in NSCLC had decreased from 61.12% in 2000-2004 to 38.90% in 2010-2014(P=0.000) . AD had increased from 36.82% to 60.10% (P=0.000) . The proportion of 637(17.66%) cases of small cell lung cancer (SCLC) had no significant difference (P=0.194) . In CLC,there were 1 039 (49.93%) cases of SCC,483 (23.21%) cases of AD and 493(23.69%) cases of SCLC. In CLC,the proportions of SCC had decreased from 63.57% to 42.44% (P=0.000) ; AD had increased from 14.29% to 28.36% (P=0.000) ; SCLC had increased from 17.38% to 26.38% (P=0.002) . In PLC,the proportions of SCC had decreased from 25.32% to 16.89%(P=0.014) ; AD had increased from 57.81% to 70.52% (P=0.001) . There were 2 519(69.82%) male and 1 089(30.18%) female patients. The proportions of male patients had decreased from 75.80% to 67.18% (P=0.000) but the proportions of female patients had increased from 24.20% to 32.82% (P=0.000) . SCC was more common in men but AD was more common in women. In male and female patients,SCC had a downward trend (P=0.000,P=0.000) ,AD was on the rise(P=0.000,P=0.000) . The onset age of SCC and SCLC had showed a trend of increase (P=0.002,P=0.000) . SCC,AD and SCLC were more common in elderly people(≥60 years old). The constituent ratio of smoking in AD patients had a downward trend (P=0.042) .

The proportion of CLC decreases gradually,while PLC presents a rising tendency; in CLC,SCC proportion decreases gradually but AD and SCLC increases obviously; in PLC,SCC proportion decreases gradually and AD increases obviously,while SCLC has no change. In NSCLC,SCC proportion has a downward trend,AD has a rising tendency,while SCLC has no significant difference. The number of male patients decreases but female patients increases gradually. There was no younger tendency in all types of lung cancer. The constituent ratio of smoking patients with SCC and SCLC has no changes while decreases in AD patients.