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WU Xueliang, WANG Likun, XUE Jun, YANG Dongdong, QU Ming, GUO Fei, ZHANG Pengcheng, HAN Lei, LIU Bo. Expression and Correlation Studies of Id-1, MMP-9, and LMVD in Colorectal Adenocarcinoma Tissues[J]. Cancer Research on Prevention and Treatment, 2016, 43(11): 959-963. DOI: 10.3971/j.issn.1000-8578.2016.11.008
Citation: WU Xueliang, WANG Likun, XUE Jun, YANG Dongdong, QU Ming, GUO Fei, ZHANG Pengcheng, HAN Lei, LIU Bo. Expression and Correlation Studies of Id-1, MMP-9, and LMVD in Colorectal Adenocarcinoma Tissues[J]. Cancer Research on Prevention and Treatment, 2016, 43(11): 959-963. DOI: 10.3971/j.issn.1000-8578.2016.11.008
shu

Expression and Correlation Studies of Id-1, MMP-9, and LMVD in Colorectal Adenocarcinoma Tissues

  • 1.

    Department of Vascular Gland Surgery,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China

  • 2.

    Department of Ultrasound,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China

  • 3.

    Department of Pathology,The First Affiliated Hospital of Hebei North University,Zhangjiakou 075000,China

More Information
  • Corresponding author:

    XUE Jun,E-mail: yfyxuejun@163.com

  • Received Date: July 01, 2016
  • Revised Date: September 08, 2016
  • Available Online: February 04, 2024
    Abstract
  • Objective 

    To explore the expressions of Id-1 and MMP-9 in colorectal carcinoma tissues and their correlation with lymphatic microvessel generation,and their clinical significance.

    Methods 

    The expression of Id-1,MMP-9 and LMVD in colorectal adenocarcinoma tissues(50 cases) and colorectal peri-cancer tissues(50 cases) were examined by immunohislochemistry. Using D-240 mRNA as a marker,the LMVD value of colorectal adenocarcinoma tissues was measured.

    Results 

    The positive expression of Id-1 and MMP-9 were 72.00% and 78% in colorectal adenocarcinoma tissues,which was significant higher than 24.00% and 28.00% in colorectal peri-cancer tissues(all P＜0.01) . The LMVD value was (15.18±2.16) in colorectal adenocarcinoma tissues markedly higher than (5.24±1.09) in colorectal peri-cancer tissues(P＜0.01) . Expression of Id-1,MMP-9 and LMVD value were correlated with the depth of tumor invasion,TNM stage,lymph node metastasis,vessel invasion,and liver metastasis(all P＜0.01) . The LMVD value in Id-1 positive expression group was significantly higher than in Id-1 negative expression group (P＜0.01) . And the LMVD value in MMP-9 positive expression group was obviously higher than in MMP-9 negative expression group in colorectal adenocarcinoma tissues (P＜0.01) . The expression of Id-1 was obviously correlated with MMP-9 in colorectal adenocarcinoma tissues.

    Conclusion 

    The high expression levels of Id-1 and MMP-9 have a close correlation with the invasion and metastasis of colorectal carcinoma. The up-regulation of them may play an important role in lymphatic microvessel generation and lymph node metastasis in colorectal carcinoma.

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    • References (42)
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