Effect of Dezocine Combined with Tramadol in Intravenous Patient-controlled Analgesia for Lung Cancer Patients after Thoracotomy

Objective  To investigate the efficacy and safety of Dezocine combined with Tramadol in intravenous patient-controlled analgesia for the lung cancer patients.

Methods  Eighty American Society of Anesthesia(ASA) patients undergoing thoracotomy were randomly divided into two groups: Dezocine plus Tramadol group(Observation group) (Dezocine 25mg+Tramadol 1g+tropisetron 10mg, n=40), and Sufentanil plus Tramadol group（Control group）(Sufentanil 50μg and Tramadol 1g+ tropisetron 10mg, n=40). In both groups, the background infusion was 2ml/h and bolus was 1ml with a locktime of 15 minutes. Observations were made at 6, 12, 24 and 48h after surgery monitoring postsurgical stats such as vitals, pain levels, medical dosage, etc. VAS and Ramsey scale were used to evaluate the analgesia response and sedation. Adverse effects and PCIA（patient-controlled intravenous analgesia）numbers were also recorded.

Results  There was no significant difference in the score of visual analogue scales (VAS) between two groups (P>0.05). The Ramsay score in the control group was significantly higher than that in the Dezocine plus Tramadol group at 6h after operation (P<0.05). The PCA numbers in the control group was significantly higher than that in the Dezocine plus Tramadol group, at 6 and 12h postoperatively (P<0.05). The incidence of nausea and vomiting in the control group was significantly higher than that in Dezocine plus Tramadol group, at 6 and 12h postoperatively (P<0.05).

Conclusion  Compared with Sufentanil, Dezocine combined with Tramadol demonstrates similar effects on postoperative intravenous patient-controlled anesthesia for lung cancer patients. Moreover, it has shown better sedative effect and low incidence of adverse reactions.