Effects of Human Chorionic Gonadotropin on Growth of Papillary Thyroid Carcinoma

Objective To research the effects of human chorionic honadotropin（hCG）on proliferation and cell cycle of papillary thyroid carcinoma. Methods The thyroid cancer cell line IHH-4 was involved in this experiment. Tetrazolium-based colorimetric assay (MTT) and flow cytometry (FCM) were used to test the effects of hCG on proliferation activity and cell cycle of IHH-4 at different concentration for 24,48 and 72 h, respectively. Results hCG could promote cell viability of IHH-4, significantly at the concentration of 100 IU/ml. Treated with hCG in concentration of 100 IU/ml for 48h, G2M+S phase of IHH-4 cells were 67.1%, significantly higher than control group. Conclusion Human Chorionic Honadotropin（hCG）could promote proliferation activity and accelerate cell cycle of papillary thyroid carcinoma cell.