Effect of Three-drug Combination Chemotherapy in Advanced Non-small Cell Lung Carcinoma with Neuroendocrine Differentiation Treatment

Objective To observe the short-term efficacy, long-term efficacy and adverse reactions of the three-drug combination chemotherapy in the treatment of the advanced non-small cell lung carcinoma with neuroendocrine differentiation(NSCLC-ND). Methods Nineteen patients with NSCLC-ND were treated with three-drug combination of etoposide,paclitaxel and cisplatin chemotherapy (E-TP group) and twenty patients were treated with two-drug combination of paclitaxel and cisplatin chemotherapy (TP group) . Short-term effi cacy, long-term effi cacy and adverse reaction of two chemotherapies were compared. Results The effi ciency of E-TP group was signifi cantly higher than that of TP group(47.4% vs. 15.0%，P<0.05). The disease control rate of E-TP group was apparently higher than that of TP group(94.7% vs. 70.0%,P<0.05). The median disease free survival of E-TP group was longer than that of TP group(P<0.05). The neutropenia incidence of E-TP group was signifi cantly higher than that of TP group, especially in the Ⅲ-Ⅳ degree(P<0.05). Conclusion The threedrug combination chemotherapy had higher effi cacy than TP combination in the treatment of advanced nonsmall cell lung carcinoma with neuroendocrine differentiation, and the adverse reactions could be tolerated. The three-drug combination chemotherapy could be further promoted.