Relationship between Polymorphism of MTHFR and Curative Effect of FOLFOX4 Adjuvant Chemotherapy in Postoperative Colon Cancer Patients

Objective To study the relationship between polymorphism of methylenetetrahydrofolate reductase (MTHFR) and FOLFOX4 adjuvant chemotherapy in postoperative colon cancer patients. Methods A total of 76 postoperative colon cancer patients were enrolled and recived six cycles of FOLFOX4 adjuvant chemotherapy MTHFR C677T gene polymorphism was detected by pyrophosphoric acid sequencing method. Results The three allelotypes of the MTHFR-C677T in 76 patients were C/C 47.4%（36/76）, T/C40.8%（31/76）, T/T11.8%（9/76）. The relapsed cases were 11 in C/C, 13 in T/C, 9 in T/T.The relapsed rate in T/T was similar to C/C and T/C (P=0.710). Conclusion There had no relationship between MTHFR C677T mutation and curative effect of FOLFOX4 adjuvant chemotherapy in postoperative colon cancer patients.