Expression of miRNA-200c in Gastric Cancer and Prediction of Its Target Gene RhoE

Objective To explore the expression of miRNA-200c in cancerous (T) and paired non-cancerous (N) tissues of gastric cancer,determine the correlation between miRNA-200c and clinicopathological characteristics and analyze the possible target genes. Methods Real-time PCR was used to quantify the expression of miRNA-200c.Bioinformatics was used to predict the target genes of miRNA-200c. Results miRNA-200c was significantly lower in cancerous tissues than that in the normal tissues (P<0.05).miRNA-200c was associated with histological grade.RhoE was the target gene of miRNA-200c. Conclusion Our results indicate that miRNA-200c plays an important role in gastric cancer and RhoE may serve as a target gene of miRNA-200c.