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Yin Dong, Meng Tao, Wang Qisan, Wang Fei, Aikeremu·Yusufu, Ge Lei, Zhang Guoqing. Interactions between IL-1β Gene Polymorphism and Helicobacter Pylori Infection as Well as Relationship of Helicobacter Pylori and Gene with Risk of Gastric Cancer in Han Nationalities in Xinjiang[J]. Cancer Research on Prevention and Treatment, 2012, 39(08): 976-979. DOI: 10.3971/j.issn.1000-8578.2012.08.024
Citation: Yin Dong, Meng Tao, Wang Qisan, Wang Fei, Aikeremu·Yusufu, Ge Lei, Zhang Guoqing. Interactions between IL-1β Gene Polymorphism and Helicobacter Pylori Infection as Well as Relationship of Helicobacter Pylori and Gene with Risk of Gastric Cancer in Han Nationalities in Xinjiang[J]. Cancer Research on Prevention and Treatment, 2012, 39(08): 976-979. DOI: 10.3971/j.issn.1000-8578.2012.08.024
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Interactions between IL-1β Gene Polymorphism and Helicobacter Pylori Infection as Well as Relationship of Helicobacter Pylori and Gene with Risk of Gastric Cancer in Han Nationalities in Xinjiang

  • 1.Department of Gastrointestina,Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi 830011,China,2.Department of Clinical Laboratory

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  • Received Date: September 27, 2011
  • Revised Date: December 12, 2011
    Abstract
  • Objective To evaluate the interactions between IL-1β gene polymorphism and Helicobacter pylori(Hp) as well as the relationship of Hp and IL-1β gene polymorphism with risk of gastric cancer in Han nationalities in Xinjiang. Methods Snapshot method was carried out to analysis the polymorphism of IL-1β gene in 229 cases of gastric cancer and in 256 controls.The assure Hp rapid test was used to investigate the presence of IgG antibodies to Hp. Results It is possible that incidence of gastric cancer in Han population is associated with the genetic polymorphism of IL-1β and Hp infections.In Han populations,interactions between Hp infections and gene showed that:individuals having IL-1β gene at rs3136558 site TT genotype and Hp infections had a 2.25-fold (95% CI：1.37~3.69) increased risk of developing GC compared with those who having CT+CC genotype but no Hp infections. Conclusion The interactions between the genetic polymorphism of IL-1β gene and Hp infections increase the risk of gastric cancer.
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    • References (12)
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    Corresponding author: Zhang Guoqing, zgqprofessor@sina.com

    • 1.Department of Gastrointestina,Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi 830011,China,2.Department of Clinical Laboratory

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