Analysis of Clinicopathological Characteristics and Prognosis for Triple Negative Breast Cancer： Report of 178 Cases

Objective To investigate the clinicopathological characteristics，survival and prognostic factors of patients with triple negative breast cancer(TNBC). Methods One hundred and seventy-eight patients who were diagnosed as breast cancer with negative estrogen receptor (ER)，progesterone receptor (PR)，and human epidermal growth factor receptor-2 (HER2) at Peking university third hospital were enrolled to collect clinicopathological factors and survival status.Clinical characteristics and prognostic factors were analyzed. Results Four patients had breast cancer family history. One hundred and fifty-five patients (87.1%) had invasive ductal carcinomas，which was the majority of pathological types.53.1% TNBC patients were grade Ⅲ，and 160 (89.9%) of the tumors were staged T1 or T2.The median clinical tumor size was2.8 cm(0.2～12 cm）.One hundred and eight patients(61.7%）had no lymph node metastasis.According to TNM staging system，60 patients (33.7%) were stage Ⅰ，81 patients (45.5％) were stage Ⅱ，and 31 patients (17.4%) were stage Ⅲ.58 patients (48.3％) had positive p53.With median follow up time of 74.0 months (range 10～156 months)，the 5-year cumulative disease free survival (DFS) of all patients was 76.9%.5-year cumulative overall survival (OS) was 86.1%.T stage，TNM stage and lymph node metastasis status were all correlated with DFS and OS in the univariate analysis.In the multivariate analysis，the lymph node metastasis status was found to be an independent prognostic factor for both DFS and OS，and clinical stage was an independent prognostic factor for OS.In total，41 patients were recorded with tumor relapse or metastasis or a second primary tumor.The common metastasis sites were bones，local recurrence or ipsilateral supraclavicular node，lung or pleural，liver and brain. Conclusion In these TNBC patients，the tumors were small，and more than half were low-histology stage.The main recurrence or metastasis sites were bones，local region and lung.Lymph node metastasis and TNM stage were both independent prognostic factors for OS.