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YANG Zhen-yu, ZHANG Xu, SHENG Chang. Meta-analysis of Association of 8q24 rs1447295A/C Polymorphism and Risk of Prostate Cancer in Asian Men　[J]. Cancer Research on Prevention and Treatment, 2011, 38(06): 706-708. DOI: 10.3971/j.issn.1000-8578.2011.06.027
Citation: YANG Zhen-yu, ZHANG Xu, SHENG Chang. Meta-analysis of Association of 8q24 rs1447295A/C Polymorphism and Risk of Prostate Cancer in Asian Men　[J]. Cancer Research on Prevention and Treatment, 2011, 38(06): 706-708. DOI: 10.3971/j.issn.1000-8578.2011.06.027
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Meta-analysis of Association of 8q24 rs1447295A/C Polymorphism and Risk of Prostate Cancer in Asian Men　

  • Department of Urology, People's Hospital of Pudong New Area, Shanghai 201200, China

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  • Received Date: April 29, 2010
  • Revised Date: November 15, 2010
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  • ObjectiveTo investigate the association of the rs1447295 locus polymorphism in the 8q24 chromosome and the risk of prostate cancer by means of Meta-analysis. MethodsAn electric search was performed in PubMed and CNKI database at the end of Dec 2009.All analyses were conducted with Review Manager Version 4.2 software. Results4 literatures with 3 different ethnic groups were studied, totally including the PCa(Prostate Cancer) group(1 391 cases) and the normal control(1 274 cases).The summary OR for studies with frequency of AA+CA genotype at rs1447295 locus in the 8q24 was 1.50(95%CI: 1.28~1.77，Z=4.92，P<0.00001). ConclusionThe meta-analysis suggests that the polymorphism at the rs1447295 locus of 8q24 might be a genetic risky factor for prostate cancer in Asian men.
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