A Meta Analysis of Relationship between COX-2 Expression and Lymph Node Metastasis in Gastric Cancer

ObjectiveTo investigate the relationship between COX-2 expression and lymph node metastasis in gastric cancer．MethodsAll available literatures using randomized clinical controlled trails including COX-2, lymph node metastasis in gastric carcinoma from January 2005 to 2009 were analyzed．According to the inclusion criteria, 13 studies were selected and data analyzed by RevMan 5.0.17 software．ResultsCOX-2 in gastric cancer tissues was significantly higher than that in normal tissues, OR=24.70,95% CI：15.93~38.31. In the tumor metastasis group COX-2 expression was significantly higher compared with no metastasis group, OR=4.94,95% CI： 3.50~6.77. Conclusion Over-expression of cyclooxygenase-2 significantly related to gastric carcinoma and lymph node metastasis.