Correlations between Expression of survivin and Microvessel Density in Thyroid Carcinoma

Objective To evaluate the relationship between survivin expression and angiogenesis as well as clinicopathological characteristics of differentiated thyroid carcinoma DTC through analysing the expression of survivin and microvessel density (MVD) of DTC. Methods Survivin and CD34 expressions were examined immunohistochemically in tissue samples from 56 DTC patients and 10 normal cases. Meantime, the relationship between expressions of survivin and CD34 and clinicopathological characteristics of patients were analyzed. Results Expression rate of survivin protein was 75%(42/56) in DTC, and survivin was negative in 10 normal thyroid tissues. Expression rate of survivin was significantly related to the advanced DTC, and cN+ DTC ，and the DTC with extracapsular invasion. The MVD was significantly higher in DTC than that in normal thyroid tissue. Conclusion The Survivin expression and MVD were upregulated in DTC, indicating survivin was involved to angiogenesis and progress of DTC.